7/1/2023 0 Comments Survivor by jf gonzalezAt the molecular level, ribosome hibernation involves the dimerization of two 70S ribosomes into a 100S ribosome dimer (disome). Similarly, in response to nutrient deprivation and other environmental stresses, ribosomes enter into a so-called hibernating state that presumably inhibits protein synthesis (Wada et al, 1990). In response to metabolic stress and energy depletion, for example, the adenosine diphosphate (ADP)-bound form of an adenosine triphosphatase (ATPase) regulatory translation factor known as energy-dependent translational throttle A (EttA) binds to ribosomes and blocks their ability to catalyze protein synthesis (Boel et al, 2014 Chen et al, 2014). Consistent with their evolutionary success, bacteria have developed numerous strategies for coping with the various types of stresses they continuously encounter. In their native habitats, bacteria are constantly subjected to environmental insults-from temperature fluctuations to dehydration to nutrient deprivation to antibiotic attacks. Nowhere in nature is the capacity to endure extreme environmental conditions more central to survival than in the microbial world.
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